Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

作者:Dou, Xiaowei; Yao, Weijun; Zhou, Bo; Lu, Yixin*
来源:Chemical communications, 2013, 49(80): 9224-9226.
DOI:10.1039/c3cc45369c

摘要

Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.

  • 出版日期2013