New glycosyl-alpha-aminotetrazole-based catalysts for highly enantioselective aldol reactions

作者：Wynands Lucie; Delacroix Sebastien; Albert Nguyen Van Nhien^*; Soriano Elena; Marco Contelles Jose; Postel Denis

来源：Tetrahedron, 2013, 69(24): 4899-4907.

DOI：10.1016/j.tet.2013.04.043

• alpha-Aminotetrazole
• Aldolisation
• Carbohydrate
• DFT calculation

Direct aldol reactions of acetone with aromatic aldehydes have been achieved in high yielding and enantioselective processes using glycosyl-alpha-aminotetrazoles as a new class of organocatalysts. Computational studies at DFT level have been performed to account for the experimental observations.

• 出版日期2013-6-17