Diagnosis of Ischemia-Causing Coronary Stenoses by Noninvasive Fractional Flow Reserve Computed From Coronary Computed Tomographic Angiograms Results From the Prospective Multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) Study

作者：Koo Bon Kwon; Erglis Andrejs; Doh Joon Hyung; Daniels David V; Jegere Sanda; Kim Hyo Soo; Dunning Allison; DeFrance Tony; Lansky Alexandra; Leipsic Jonathan; Min James K^*

来源：Journal of the American College of Cardiology, 2011, 58(19): 1989-1997.

DOI：10.1016/j.jacc.2011.06.066

• computational fluid dynamics
• coronary CT angiography
• fractional flow reserve

Objectives
The aim of this study was to determine the diagnostic performance of a new method for quantifying fractional flow reserve (FFR) with computational fluid dynamics (CFD) applied to coronary computed tomography angiography (CCTA) data in patients with suspected or known coronary artery disease (CAD).
Background
Measurement of FFR during invasive coronary angiography is the gold standard for identifying coronary artery lesions that cause ischemia and improves clinical decision-making for revascularization. Computation of FFR from CCTA data (FFRCT) provides a noninvasive method for identifying ischemia-causing stenosis; however, the diagnostic performance of this new method is unknown.
Methods
Computation of FFR from CCTA data was performed on 159 vessels in 103 patients undergoing CCTA, invasive coronary angiography, and FFR. Independent core laboratories determined FFRCT and CAD stenosis severity by CCTA. Ischemia was defined by an FFRCT and FFR <= 0.80, and anatomically obstructive CAD was defined as a CCTA with stenosis >= 50%. Diagnostic performance of FFRCT and CCTA stenosis was assessed with invasive FFR as the reference standard.
Results
Fifty-six percent of patients had >= 1 vessel with FFR <= 0.80. On a per-vessel basis, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 84.3%, 87.9%, 82.2%, 73.9%, 92.2%, respectively, for FFRCT and were 58.5%, 91.4%, 39.6%, 46.5%, 88.9%, respectively, for CCTA stenosis. The area under the receiver-operator characteristics curve was 0.90 for FFRCT and 0.75 for CCTA (p = 0.001). The FFRCT and FFR were well correlated (r = 0.717, p < 0.001) with a slight underestimation by FFRCT (0.022 +/- 0.116, p = 0.016).
Conclusions
Noninvasive FFR derived from CCTA is a novel method with high diagnostic performance for the detection and exclusion of coronary lesions that cause ischemia. (T

• 出版日期2011-11-1