科研之友
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摘要
The objective of this study was to evaluate the feasibility of a new xenograft material Ti-OssA (R)(Chiyewon, Guri, Korea) by investigating the degree of new bone formation compared with that of other commonly used xenografts Bio-OssA (R)(Geistlich Pharma AG, Wolhusen, Switzerland) and OCS-BA (R)(NIBEC, Seoul, Korea). Forty rats were used in the study. The animals were randomly allocated into four groups of 10 animals each. The Group 1%26apos;s calvarial defect was untreated, Group 2%26apos;s defect was filled with Bio-OssA (R)(Geistlich Pharma AG), Group 3%26apos;s defect was filled with OCS-BA (R)(NIBEC), and Group 4%26apos;s defect was filled with Ti-OssA (R)(Chiyewon). The animals were sacrificed at 2 (n=5) and 8 (n=5) weeks for histomorphometric analysis. The histomorphometric analysis showed the statistically significant difference between the groups with a mean bone formation of 0.35 +/- 0.10 mm (8.75%) for Bio-OssA (R) group, 0.19 +/- 0.04 mm (4.75%) for OCS-BA (R) group, 0.26 +/- 0.04 mm (6.5%) for Ti-OssA (R) group at 2 week healing period. At 8 weeks, a mean bone formation of 1.93 +/- 0.18 mm (48.25%) for Bio-OssA (R) group, 1.12 +/- 0.11 mm (28%) for OCS-BA (R) group, 1.50 +/- 0.28 mm (37.5%) for Ti-OssA (R) group showed the statistically significant difference (p %26lt; 0.05). Within the limits of present study, it was concluded that the newly investigated xenograft, Ti-OssA (R), revealed biocompatibility and effectiveness in bone formation. Ti-OssA (R) could be proposed as a potential material for filling osseous defects. Further clinical trials of the new bovine xenograft Ti-OssA (R) are needed for an understanding its relevance in dentistry.
- 出版日期2012-10
