Advances in intrathecal drug delivery

作者：De Andres Jose^*; Asensio Samper Juan M; Fabregat Cid Gustavo

来源：Current Opinion in Anaesthesiology, 2013, 26(5): 594-599.

DOI：10.1097/ACO.0b013e3283625ec7

• baclofen
• cerebrospinal fluid kinetics
• chronic pain
• intrathecal drug delivery system
• local anesthesthetics
• mixture of spinal drug targeting
• opioids
• spasticity
• spinal drugs
• ziconotide

Purpose of reviewTargeted intrathecal drug delivery systems (IDDS) are an option in algorithms for the treatment of patients with moderate-to-severe chronic refractory pain. This article is intended to review the literature regarding IDDS published over the last year, with special attention to the Polyanalgesic Consensus Conference 2012.Recent findingsThe recommendations made by the Polyanalgesic Consensus Conference 2012 are reviewed. Separate considerations of intrathecal drug therapy for neuropathic and nociceptive pain syndromes and the new concept of microdosing%26apos; are discussed in this article.SummaryThis review includes the recommendations for the use of IDDS, trialing, and recent reports of complications (especially, the occurrence of granulomas). In addition, the latest documents on cerebrospinal fluid and potential lines of future development are discussed.

• 出版日期2013-10