A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

作者：Wang, Guanghui; Guo, Xiaoyu; Chen, Haifeng; Lin, Ting; Xu, Yang; Chen, Quancheng; Liu, Jie; Zeng, Jinzhang; Zhang, Xiao-kun^*; Yao, Xinsheng

来源：Bioorganic & Medicinal Chemistry Letters, 2012, 22(5): 2114-2118.

DOI：10.1016/j.bmcl.2011.12.095

• Phoyunbene B
• Resveratrol
• Cell cycle
• Apoptosis

Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis R-OLFE, we found phoyunbene B (PYB, trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells.

• 出版日期2012-3-1
• 单位厦门大学; 暨南大学; 北京大学