Accelerating chemical reactions by molecular sledding

作者:Zhang, Lei; Zheng, Lifei*; Meng, Zhuojun; Balinin, Konstantin; Loznik, Mark; Herrmann, Andreas*
来源:Chemical Communications, 2017, 53(47): 6331-6334.
DOI:10.1039/c7cc02500a

摘要

The speed-up of covalent bond formation was achieved between a sulfhydryl group and a 2-bromopropionic acid derivative by utilizing sliding peptide-modified substrates. Moreover, a new type of DNA cleaving reagent was developed, consisting of pVIc covalently coupled to verteporfin. This peptide-porphyrin conjugate allowed targeting of DNA and resulted in increased photodegradation of double-stranded nucleic acids.