Stability of 0.5% cidofovir stored under various conditions for up to 6 months

作者：Stiles Jean^*; Gwin Wilson; Pogranichniy Roman

来源：Veterinary Ophthalmology, 2010, 13(4): 275-277.

• antiviral activity
• cidofovir
• feline herpesvirus
• stability
• virus titration

Objective To evaluate the effect of time, temperature and storage vial material on the antiviral activity of 0.5% cidofovir solution.
Procedures Commercial 7.5% cidofovir solution for injection was diluted with normal saline to a 0.5% concentration. Aliquots were stored in plastic and glass vials at 4, -20, and -80 degrees C for 30, 60, 120, and 180 days. Antiviral activity against feline herpesvirus was evaluated in a virus titration assay at time zero (baseline) and at each subsequent time point.
Results Cidofovir caused a fourfold log reduction in virus titer at baseline and at each time point and for each storage condition (P < 0.001).
Conclusion 0.5% cidofovir demonstrated stable antiviral activity when stored for up to 6 months in glass or plastic, at 4, -20, and -80 degrees C.

• 出版日期2010-7