An association between volumes of the cardiac chambers and troponin levels in individuals submitted to cardiac coronary computed tomography

作者：Rozenbaum Zach^*; Arbel Yaron; Granot Yoav; Cohen Dotan; Shmilovich Haim; Ziv Baran Tomer; Chorin Ehud; Havakuk Ofer; Cohen Merav; Berliner Shlomo; Topilsky Yan; Aviram Galit

来源：Clinical Cardiology, 2017, 40(10): 879-885.

DOI：10.1002/clc.22739

• Computed Tomography
• Troponin
• Volumetric Analysis

BackgroundPrevious echocardiographic studies have revealed an association between enlarged cardiac chamber volumes and elevated troponin concentrations. An automatic 4-chamber volumetric analysis tool was adopted to investigate this association in patients who underwent cardiac-gated computed tomography angiography (CCTA).
HypothesisWe hypothesized that troponin concentration within the normal range correlates with cardiac chambers' volumes.
MethodsSerum troponin was obtained from 157 ambulatory patients before undergoing CCTA for nonacute coronary artery evaluation. Volumes of the cardiac chambers and the left ventricular mass were automatically analyzed and indexed to body surface area. Patients with a troponin concentrations within the upper quartile (>0.007 ng/mL, n = 39) were compared to patients with a troponin concentrations within the 3 lower quartiles of troponin concentrations (0.007 ng/mL, n = 118).
ResultsNone of the patients had a troponin concentration >0.05 ng/mL (the 99th percentile of the general population). There were no significant differences in baseline characteristics between the groups. There were significant correlations between troponin and ventricular volumes after adjustments for age and gender. In an analysis that included 107 patients without any known heart diseases, including those pathological findings in the current CCTA, there were significant correlations between troponin and the left and right ventricular volumes after adjustments for age, gender, and baseline characteristics (odds ratio [OR]: 1.08, 95% confidence interval [CI]: 1.03-1.14, P = 0.002 and OR: 1.11, 95% CI: 1.04-1.19, P = 0.002; respectively).
ConclusionsUsing the technology of automatic volumetric analysis in individuals undergoing CCTA, an association between larger right and left cardiac chambers and higher levels of troponin concentration was shown.

• 出版日期2017-10