Use of gemcitabine-platinum in Indian patients with advanced gall bladder cancer

作者：Sirohi Bhawna^*; Rastogi Sameer; Singh Ashish; Sheth Vipul; Dawood Shaheenah; Talole Sanjay; Ramadwar Mukta; Kulkarni Suyash; Shrikhande Shailesh V

来源：Future Oncology, 2015, 11(8): 1191-1200.

DOI：10.2217/fon.14.295

• advanced
• chemotherapy
• gall bladder cancer
• gemcitabine-platinum

Background: Gemcitabine-platinum (Gem-P) is the current standard for patients with advanced gall bladder cancer. Materials & methods: This is retrospective analysis of a prospectively maintained database of 210 patients with advanced gall bladder cancer treated with Gem-P between January 2012 and September 2013. Results: Median age was 53 years, 65.2% females. In total,158 patients had metastatic and 52 had locoregional disease. Median number of cycles was 5 (1-12). At a median follow-up of 10 months, median overall survival/progression-free survival was 10/5 months, respectively. On multivariate analysis, patients who underwent prior surgery for primary and locoregional disease had a significantly better progression-free survival and those with locoregional disease had a significantly better overall survival. A total of 45.7% received second-line chemotherapy. Conclusion: Use of Gem-P in Indian patients leads to slightly worse outcomes suggesting an aggressive biology.

• 出版日期2015