Nucleation temperature-controlled synthesis and in vitro toxicity evaluation of L-cysteine-capped Mn:ZnS quantum dots for intracellular imaging

作者：Pandey Vivek; Pandey Gajanan; Tripathi Vinay Kumar; Yadav Sapna; Mudiam Mohana Krishna Reddy^*

来源：Luminescence, 2016, 31(2): 341-347.

DOI：10.1002/bio.2965

• quantum dots
• bioimaging
• nucleation
• neuronal cells
• l-cysteine

Quantum dots (QDs), one of the fastest developing and most exciting fluorescent materials, have attracted increasing interest in bioimaging and biomedical applications. The long-term stability and emission in the visible region of QDs have proved their applicability as a significant fluorophore in cell labelling. In this study, an attempt has been made to explore the efficacy of l-cysteine as a capping agent for Mn-doped ZnS QD for intracellular imaging. A room temperature nucleation strategy was adopted to prepare non-toxic, water-dispersible and biocompatible Mn:ZnS QDs. Aqueous and room temperature QDs with l-cysteine as a capping agent were found to be non-toxic even at a concentration of 1500 mu g/mL and have wide applications in intracellular imaging.

• 出版日期2016-3