A comparison of the symptomatic profile between two consecutive depressive episodes in patients with bipolar disorder type I

作者：de Macedo Soares Marcia B^*; Brietzke Elisa; Dias Rodrigo da Silva; Mendonca Tiago; Moreira Camila; Lafer Beny

来源：Acta Neuropsychiatrica, 2010, 22(6): 280-283.

DOI：10.1111/j.1601-5215.2010.00496.x

• bipolar disorder
• bipolar depression
• symptomatology
• consistency

Objective: To compare the variability of patterns of depressive symptoms between two consecutive depressive episodes in patients with bipolar disorder type I.
Methods: Review of prospectively collected data from 136 subjects of an out-patient bipolar unit from 1997 to 2007. Binomial statistics was used for the analysis of Hamilton Depression Rating Scale (HDRS)-31 items of the first and second episodes, and the correlation of the HDRS-31 item scores of both episodes was determined using the Spearman coefficient.
Results: Ten depressive symptoms showed a significant correlation between index and subsequent episodes: psychological anxiety, somatic anxiety, somatic symptoms, diurnal variation, paranoid symptoms, obsessive and compulsive symptoms, hypersomnia, loss of appetite and helplessness. Only four symptoms were stable in both statistical tests: paranoid symptoms, obsessive-compulsive symptoms, loss of appetite and hypersomnia.
Conclusions: Paranoid and obsessive-compulsive symptoms, loss of appetite and hypersomnia tended to be found in successive episodes. However, the moderate correlations of the symptoms across two depressive recurrences suggested that clinical presentations in bipolar depression may not be predicted by symptom profiles presented in previous episodes.

• 出版日期2010-12