Aortic F-18-FDG uptake in patients suffering from granulomatosis with polyangiitis

作者：Kemna Michael J; Bucerius Jan; Drent Marjolein; Voo Stefan; Veenman Martine; van Paassen Pieter; Tervaert Jan Willem Cohen; van Kroonenburgh Marinus J P G^*

来源：European Journal of Nuclear Medicine and Molecular Imaging, 2015, 42(9): 1423-1429.

DOI：10.1007/s00259-015-3081-y

• Positron emission tomography scanning
• PET/CT
• Aortic inflammation
• Granulomatosis with polyangiitis
• ANCA-associated vasculitis
• Sarcoidosis
• Large vessel vasculitis
• Giant cell arteritis

Purpose The objective of the study was to systematically assess aortic inflammation in patients with granulomatosis with polyangiitis (GPA) using F-18-2-deoxy-2-[F-18]fluoro-D-glucose (FDG) positron emission tomography (PET)/CT.
Methods Aortic inflammation was studied in PET/CT scans obtained from 21 patients with GPA; 14 patients with sarcoidosis were included as disease controls, 7 patients with stage I or II head and neck carcinoma ascertained during routine clinical practice were used as healthy controls (HC) and 5 patients with large vessel vasculitis (LVV) were used as positive controls. Aortic F-18-FDG uptake was expressed as the blood-normalized maximum standardized uptake value (SUVmax), known as the target to background ratio (mean TBRmax).
Results The mean TBRmax (interquartile range) of the aorta in patients with GPA, sarcoidosis, HC and LVV were 1.75 (1.32-2.05), 1.62 (1.54-1.74), 1.29 (1.22-1.52) and 2.03 (1.67-2.45), respectively. The mean TBRmax was significantly higher in patients suffering from GPA or LVV compared to HC (p < 0.05 and p < 0.005, respectively) and tended to be higher in patients suffering from sarcoidosis, but this did not reach statistical significance (p = 0.098). The mean TBRmax of the most diseased segment was significantly higher compared to HC [1.57 (1.39-1.81)] in LVV patients [2.55 (2.22-2.82), p < 0.005], GPA patients [2.17 (1.89-2.83), p < 0.005] and patients suffering from sarcoidosis [2.04 (1.88-2.20), p < 0.05]. In GPA patients, the mean TBRmax of the aorta was significantly higher in patients with previous renal involvement [2.01 (1.69-2.53)] compared to patients without renal involvement in the past [1.60 (1.51-1.80), p < 0.05]. Interrater reproducibility with a second reader was high (all intraclass correlation coefficients > 0.9).
Conclusion Patients suffering from GPA show marked aortic FDG uptake.

• 出版日期2015-8