Dietary Manganese Promotes Staphylococcal Infection of the Heart

作者：Juttukonda Lillian J; Berends Evelien T M; Zackular Joseph P; Moore Jessica L; Stier Matthew T; Zhang Yaofang; Schmitz Jonathan E; Beavers William N; Wijers Christiaan D; Gilston Benjamin A; Kehl Fie Thomas E; Atkinson James; Washington Mary K; Peebles R Stokes; Chazin Walter J; Torres Victor J; Caprioli Richard M; Skaar Eric P^*

来源：Cell Host & Microbe, 2017, 22(4): 531-+.

DOI：10.1016/j.chom.2017.08.009

Diet, and specifically dietary metals, can modify the risk of infection. However, the mechanisms by which manganese (Mn), a common dietary supplement, alters infection remain unexplored. We report that dietary Mn levels dictate the outcome of systemic infections caused by Staphylococcus aureus, a leading cause of bacterial endocarditis. Mice fed a high Mn diet display alterations in Mn levels and localization within infected tissues, and S. aureus virulence and infection of the heart are enhanced. Although the canonical mammalian Mn-sequestering protein calprotectin surrounds staphylococcal heart abscesses, calprotectin is not released into the abscess nidus and does not limit Mn in this organ. Consequently, excess Mn is bioavailable to S. aureus in the heart. Bioavailable Mn is utilized by S. aureus to detoxify reactive oxygen species and protect against neutrophil killing, enhancing fitness within the heart. Therefore, a single dietary modification overwhelms vital host antimicrobial strategies, leading to fatal staphylococcal infection.

• 出版日期2017-10-11