Development of a new Lewis base-tolerant chiral LBA and its application to catalytic asymmetric protonation reaction

作者：Cheon Cheol Hong; Imahori Tatsushi; Yamamoto Hisashi^*

来源：Chemical communications, 2010, 46(37): 6980-6982.

DOI：10.1039/c0cc02492a

A new Lewis base-tolerant LBA (Lewis Acid Assisted Bronsted Acid) derived from La(OTf)(3) and (S)-HOP has been developed as a new chiral Bronsted acid. This acid has been successfully applied as a catalyst to asymmetric protonation reactions of silyl enol ethers of 2-substituted cyclic ketones.

• 出版日期2010-10-7