科研之友
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摘要
Four L-rhamnose-benzoxazinone compounds as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors were designed and synthesized. All structures of the compounds were characterized by H-1-NMR, C-13-NMR, and high-resolution mass spectrometry. The inhibition activities of the target compounds for the EGFR tyrosine kinase activity in vitro were determined. Compounds 6a-d displayed moderate activity in targeting EGFR.
- 出版日期2016-9
- 单位中国海洋大学
