A xanthate-based free radical approach to defucogilvocarcin M

作者：Cortezano Arellano Omar; Cordero Vargas Alejandro^*

来源：Tetrahedron Letters, 2010, 51(4): 602-604.

DOI：10.1016/j.tetlet.2009.11.076

A formal total synthesis of the aglycon of gilvocarcin M is described. The synthesis is based on the construction of the key naphthalene 7 via a free radical addition-cyclization protocol followed by aromatization of the resulting alpha-tetralone. This highly functionalized aromatic system is coupled to the corresponding acid chloride 6 to afford ester 4, which by treatment with a catalytic amount of palladium (0) produced defucogilvocarcin M (1a).

• 出版日期2010-1-27