科研之友
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摘要
Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10), 14(17), 22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC50 values of 68.50 and 29.69 mu M, respectively. A plausible biosynthetic pathway for 2 is also discussed.
