Asymmetric Synthesis of 2,3-Dihydro-4-pyranones by Reaction of Chiral 3-Alkoxycyclobutanone and Aldehydes

作者：Negishi Shoko; Ishibashi Hiroyuki; Matsuo Jun ichi^*

来源：Organic Letters, 2010, 12(21): 4984-4987.

DOI：10.1021/ol1021355

Chiral cyclobutanone which had ethyl L-lactate as a chiral auxiliary at the 3-position reacted with aldehydes to give 2,3-dihydro-4-pyranones in up to 93% ee by combined use of titanium(IV) chloride and tin(II) chloride.

• 出版日期2010-11-5
• 单位河北医科大学