Bipolar Transurethral Incision of Bladder Neck Stenoses with Mitomycin C Injection

作者：Lyon Timothy D; Ayyash Omar M; Ferroni Matthew C; Rycyna Kevin J; Chen Mang L

来源：Advances in Urology, 2015, 2015: 758536.

DOI：10.1155/2015/758536

<jats:p><jats:italic>Introduction</jats:italic>. To determine the efficacy of bipolar transurethral incision with mitomycin C (MMC) injection for the treatment of refractory bladder neck stenosis (BNS).<jats:italic>Materials and Methods</jats:italic>. Patients who underwent bipolar transurethral incision of BNS (TUIBNS) with MMC injection at our institution from 2013 to 2014 were retrospectively reviewed. A total of 2 mg of 40% mitomycin C solution was injected in four quadrants of the treated BNS. Treatment failure was defined as the need for subsequent intervention.<jats:italic>Results</jats:italic>. Thirteen patients underwent 17 bipolar TUIBNS with MMC injection. Twelve (92%) patients had failed a mean of 2.2 ± 1.1 prior endoscopic procedures. Median follow-up was 16.5 months (IQR: 14–18.4 months). Initial success was 62%; five (38%) patients had a recurrence with a median time to recurrence of 7.3 months. Four patients underwent a repeat procedure, 2 (50%) of which failed. Overall success was achieved in 77% (10/13) of patients after a mean of 1.3 ± 0.5 procedures. BNS recurrence was not significantly associated with history of pelvic radiation (33% versus 43%,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.9</mml:mn></mml:math>). There were no serious adverse events.<jats:italic>Conclusions</jats:italic>. Bipolar TUIBNS with MMC injection was comparable in efficacy to previously reported techniques and did not result in any serious adverse events.</jats:p>

• 出版日期2015