Amino acid profiles of young adults differ by sex, body mass index and insulin resistance

作者：Guevara Cruz M; Vargas Morales J M; Mendez Garcia A L; Lopez Barradas A M; Granados Portillo O; Ordaz Nava G; Rocha Viggiano A K; Gutierrez Leyte C A; Medina Cerda E; Rosado J L; Morales J C; Torres N; Tovar A R^*; Noriega L G^*

来源：Nutrition Metabolism and Cardiovascular Diseases, 2018, 28(4): 393-401.

DOI：10.1016/j.numecd.2018.01.001

• Amino acids
• Obesity
• Insulin resistance
• Young adults

Background and aims: An increase in plasma branched-chain amino acids is associated with a higher risk of developing type 2 diabetes and cardiovascular diseases. However, little is known about the basal plasma amino acid concentrations in young adults. Our aim was to determine the plasma amino acid profiles of young adults and to evaluate how these profiles were modified by sex, body mass index (BMI) and insulin resistance (IR).
Methods and results: We performed a transversal study with 608 Mexican young adults aged 19.9 +/- 2.4 years who were applicants to the Universidad Autonoma de San Luis Potosi. The subjects underwent a physical examination and provided a clinical history and a blood sample for biochemical, hormonal and amino acid analyses. The women had higher levels of arginine, aspartate and serine and lower levels of alpha-aminoadipic acid, cysteine, isoleucine, leucine, methionine, proline, tryptophan, tyrosine, urea and valine than the men. The obese subjects had higher levels of alanine, aspartate, cysteine, ornithine, phenylalanine, proline and tyrosine and lower levels of glycine, ornithine and serine than the normal weight subjects. Subjects with IR (defined as HOMA > 2.5) had higher levels of arginine, alanine, aspartate, isoleucine, leucine, phenylalanine, proline, tyrosine, taurine and valine than the subjects without IR. Furthermore, we identified two main groups in the subjects with obesity and/or IR; one group was composed of amino acids that positively correlated with the clinical, biochemical and hormonal parameters, whereas the second group exhibited negative correlations.
Conclusion: This study demonstrates that young adults with obesity or IR have altered amino acid profiles characterized by an increase in alanine, aspartate, proline and tyrosine and a decrease in glycine. (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V.

• 出版日期2018-4