Nonopioid effect of beta-endorphin

作者：Kovalitskaya Yu A^*; Navolotskaya E V

来源：Biochemistry-Moscow, 2011, 76(4): 379-393.

DOI：10.1134/S0006297911040018

• beta-endorphin peptides
• naloxone-insensitive receptor
• immune system
• nervous system
• adrenal glands

This review presents the generalized literature data and the results of our own research of the nonopioid effect of beta-endorphin, an opioid neuropeptide interacting not only with opioid but also with nonopioid (insensitive to the opioid antagonist naloxone) receptors. The roles of the hormone and its receptors in regulation of the immune, nervous, and endocrine systems are discussed. The effect of neuromediator on the immune system mediated by both opioid and nonopioid receptors is considered in detail. The data on distribution and function of the nonopioid beta-endorphin receptor in human and animal organisms are presented. All available data on the characteristics of the nonopioid beta-endorphin receptor obtained by means of radioligand analysis are given. The discussed information is supposed to extend our conceptions of the role of beta-endorphin in mammals and to be of extensive use in medicine and pharmacology.

• 出版日期2011-4