The demyelination neurophysiological criteria can be misleading in Campylobacter jejuni-related Guillain-Barre syndrome

作者：Kokubun Norito^*; Shahrizaila Nortina; Koga Michiaki; Hirata Koichi; Yuki Nobuhiro

来源：Clinical Neurophysiology, 2013, 124(8): 1671-1679.

DOI：10.1016/j.clinph.2013.02.010

• Acute motor axonal neuropathy
• Acute inflammatory demyelinating
• polyneuropathy
• Campylobacter jejuni
• Guillain-Barre syndrome

Objective: The exclusive association of Campylobacter jejuni infection with the axonal variant of Guillain-Barre syndrome (GBS) is debatable. The current study aims to elucidate the GBS subtypes of patients with an antecedent C. jejuni infection. %26lt;br%26gt;Methods: Nerve conduction study results of 73 patients with GBS were reviewed. Patients were defined as having a recent C. jejuni infection when there was a positive stool culture or serological evidence of C. jejuni in the presence of preceding diarrhea. %26lt;br%26gt;Results: A total of 23 patients had evidence of a recent C. jejuni infection. At the early stage, patients were classified as AMAN (n = 9; 39%), AIDP (n = 3; 13%) or equivocal (n = 9) using existing electrophysiological criteria. Prolonged distal latencies and conduction slowing that were seen in 11 patients rapidly normalized within 3 weeks in seven, whereas four had minor abnormalities throughout the course. Subsequently, all patients showed either acute motor axonal neuropathy pattern or reversible conduction failure. %26lt;br%26gt;Conclusion: Serial neurophysiology suggests that C. jejuni infections are exclusive to axonal GBS. %26lt;br%26gt;Significance: Our findings suggest that AMAN can demonstrate the full complement of demyelinating features at the early stages of disease.

• 出版日期2013-8