Alzheimer dementia with sparse amyloid-AD mimic or variant?

作者:Serrano Pozo Alberto; Hyman Bradley T
来源:Nature Reviews Neurology, 2015, 11(12): 674-675.
DOI:10.1038/nrneurol.2015.221

摘要

In a new study, one-quarter of individuals with a clinical diagnosis of mild to moderate Alzheimer dementia had no or only sparse neuritic amyloid plaques in their brains, and most were also at a low or an intermediate neurofibrillary tangle stage. The findings have enormous implications for clinical trials of anti-amyloid-beta and anti-tau therapies.

  • 出版日期2015-12