Alkaloids and Flavonoids as alpha(1)-Adrenergic Receptor Antagonists

作者：Li W; Du L; Li M^*

来源：Current Medicinal Chemistry, 2011, 18(32): 4923-4932.

• alpha(1)-adrenergic receptor
• antagonist
• natural products
• alkaloids
• flavonoids

Since the subtypes of alpha(1)-adrenergic receptor have been thoroughly determined, to date medicinal chemists raise their deliberation on how to conceive selective alpha(1)-adrenergic receptor antagonist with the minimal side effects. It needs to be well recognized that natural products can exist as a significant source of drug leads, thus portraying a consequential capacity in drug design and development. The current review article would like to present a comprehensive survey on natural products, mainly including alkaloids and flavonoids, which exhibit alpha(1)-adrenergic receptor antagonistic activities.

• 出版日期2011-11
• 单位山东大学