A DISCUSSION ON CHEMOPREVENTION OF ORAL CANCER BY SELECTIVE CYCLOOXYGENASE-2 (COX-2) INHIBITORS

作者：Singh A K; Pandey A; Tewari M; Prakash Kumar; Shukla H S; Pandey H P^*

来源：Digest Journal of Nanomaterials and Biostructures, 2010, 5(2): 285-295.

• Cyclooxygenase
• Selective COX-2 inhibitors
• Oral cancer
• Chemoprevention

Oral cancers are potentially fatal diseases, have a high mortality rate and because of this it is highly challenging for the clinicians. Cyclooxygenase (COX), the key enzyme in prostaglandin cascade, is expressed in two isoform: the constitutive COX-1 and inducible COX-2. COX-2 expression extensively up regulated in oral cancer, oral premalignant lesion and seemed to be enhanced specifically in high-risk oral lesions. In recent studies it has been found that Zinc regulates COX-2 expression in vivo, in animal model may lead to prevention or therapeutic possibilities for upper aerodigestive tract cancer. The data in recent literatures strongly indicate that COX-2 expression is extensively up-regulated in oral cancer and it is believed that COX-2 inhibition strongly suppressed the oral lesion therefore; selective COX-2 inhibitor should be investigated as new chemopreventive agents for patient who are at high risk for developing oral cancer.

• 出版日期2010-6
• 单位河北医科大学