Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture

作者：Costanzo M; Cisterna B; Zharskaya O O; Zatsepina O V; Biggiogera M^*

来源：European Journal of Histochemistry, 2011, 55(2): 82-84.

DOI：10.4081/ejh.2011.e15

• nucleolus
• RNase
• electron microscopy
• immunocytochemistry

We have studied by means of ultrastructural immunocytochemistry the localization of RNase A in nuclei of He La cells in control conditions and following cell ageing in culture. We have found that roundish, electron dense foci, which contain a significant amount of RNase A, can be detected within nucleoli of aged cells. These bodies also contain RNA and lack ribosomal S3 proteins, and may represent either simple storage sites or areas where RNA degradation takes place.

• 出版日期2011-6