Hyaluronan Modified Calcium Carbonate Nanoparticles Loaded with Adriamycin for Chemotherapy of Gastric Cancer

作者：Fu, Yongmei; Liang, Caiqian; Xing, Bangrong; Liu, Zhiyong; Tang, Wenjie^*; Huang, Jianglong^*; Jin, Yi^*

来源：Journal of Biomaterials and Tissue Engineering, 2017, 7(9): 814-821.

DOI：10.1166/jbt.2017.1641

• Calcium Carbonate
• Hyaluronan
• Gastric Cancer
• Adriamycin

A tumor-targeting drug delivery system (DDS) composed of hyaluronan (HA) and calcium carbonate (CC) nanoparticles that loaded with adriamycin (Adr) was developed to take advantage of the tumor-targeting ability of HA and drug-loading property of CC for potential gastric cancer therapy. Our experimental results indicated that the drug loading efficiency of HA-CC/Adr nanoparticles was relatively high that is beneficial for the following administration. On the other hand, HA-CC/Adr nanoparticles can increased the uptake ratio of Adr into MKN45 gastric cancer cells compare to bare CC/Adr nanoparticles, possibly via the CD44 receptor-mediated endocytosis. Thus, HA-CC/Adr nanoparticles exhibited stronger anti-cancer activity in vivo than free Adr or CC/Adr nanoparticles with minimized toxic side effects and preferable tumor-suppression potential on tumor-bearing nude mice model.

• 出版日期2017-9
• 单位中山大学