Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells

作者：Salio Mariolina; Gasser Olivier; Gonzalez Lopez Claudia; Martens Anne; Veerapen Natacha; Gileadi Uzi; Verter Jacob G; Napolitani Giorgio; Anderson Regan; Painter Gavin; Besra Gurdyal S; Hermans Ian F; Cerundolo Vincenzo

来源：The Journal of Immunology, 2017, 199(8): 2631-2638.

DOI：10.4049/jimmunol.1700615

Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize intermediates of the vitamin B2 biosynthetic pathway presented by the monomorphic MR1 molecule. It remains unclear whether, in addition to their cytolytic activity that is important in antimicrobial defense, MAIT cells have immune-modulatory functions that could enhance dendritic cell (DC) maturation. In this study, we investigated the molecular mechanisms dictating the interactions between human MAIT cells and DCs and demonstrate that human MAIT cells mature monocyte-derived and primary DCs in an MR1-and CD40L-dependent manner. Furthermore, we show that MAIT cell-derived signals synergize with microbial stimuli to induce secretion of bioactive IL-12 by DCs. Activation of human MAIT cells in whole blood leads to MR1-and cytokine-dependent NK cell transactivation. Our results underscore an important property of MAIT cells, which can be of translational relevance to rapidly orchestrate adaptive immunity through DC maturation.

• 出版日期2017-10-15
• 单位河北医科大学