Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon

作者：Wang Xiao hua^*; Yin Yuan qin; Ma Ping; Sui Cheng guang; Meng Fan dong; Jiang You hong

来源：Chinese Journal of Cancer Research, 2009, 21(3): 224-228.

DOI：10.1007/s11670-009-0224-3

• All-trans retinoic acid (ATRA)
• Interferon-alpha (IFN-alpha)
• Apoptosis
• Human pancreatic carcinoma cells

To investigate the apoptosis of human pancreatic carcinoma PC3 cells induced by the combination of all-trans retinoic acid (ATRA) with interferon alpha (IFN-alpha).
PC3 cells were treated with ATRA and IFN-alpha. The inhibitory rate of PC3 cell proliferation was detected using MTT method. Cellular apoptosis was determined with flow cytometry. The percentage of PC3 cell apoptosis was assayed using TUNEL methods.
ATRA and IFN-alpha could inhibit cellular proliferation and induces cellular apoptosis of PC3 cells. The inhibitory effect was stronger when the ATRA and IFN-alpha were combined as a therapy.
ATRA inhibits the proliferation of PC3 cells and induce the apoptosis of PC3 cells. The combination of IFN-alpha with ATRA may enhance these effects on PC3 cells.

• 出版日期2009-9
• 单位中国医科大学