A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus

作者：Samad Rozanah Asmah Abdul; Nomura Naoki; Tsuda Yoshimi; Manzoor Rashid; Kajihara Masahiro; Tomabechi Daisuke; Sasaki Takashi; Kokumai Norihide; Ohgitani Toshiaki; Okamatsu Masatoshi; Takada Ayato; Sakoda Yoshihiro; Kida Hiroshi^*

来源：Japanese Journal of Veterinary Research, 2011, 59(1): 23-29.

• Antigenically drifted HPAIV
• vaccine

Inactivated influenza virus vaccine prepared from a non-pathogenic influenza virus strain A/duck/Hokkaido/Vac-1/2004 (H5N1) from the virus library conferred protective immunity to chickens against the challenge of antigenically drifted highly pathogenic avian influenza virus (HPAIV), A/whooper swan/Hokkaido/1/2008 (H5N1). The efficacy of the vaccine was comparable to that prepared from genetically modified HPAIV strain Delta RRRRK rg-A/whooper swan/Mongolia/3/2005 (H5N1), which is more antigenically related to the challenge virus strain, in chickens.

• 出版日期2011-2