Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events

作者：Sobolev Olga; Binda Elisa; O'Farrell Sean; Lorenc Anna; Pradines Joel; Huang Yongqing; Duffner Jay; Schulz Reiner; Cason John; Zambon Maria; Malim Michael H; Peakman Mark; Cope Andrew; Capila Ishan; Kaundinya Ganesh V; Hayday Adrian C^*

来源：Nature Immunology, 2016, 17(2): 204-213.

DOI：10.1038/ni.3328

Adjuvanted vaccines afford invaluable protection against disease, and the molecular and cellular changes they induce offer direct insight into human immunobiology. Here we show that within 24 h of receiving adjuvanted swine flu vaccine, healthy individuals made expansive, complex molecular and cellular responses that included overt lymphoid as well as myeloid contributions. Unexpectedly, this early response was subtly but significantly different in people older than similar to 35 years. Wide-ranging adverse clinical events can seriously confound vaccine adoption, but whether there are immunological correlates of these is unknown. Here we identify a molecular signature of adverse events that was commonly associated with an existing B cell phenotype. Thus immunophenotypic variation among healthy humans may be manifest in complex pathophysiological responses.

• 出版日期2016-2