Ultrasound-assisted synthesis of substituted guanidines using 1H-pyrazole-1-carboxamidine and S-methylisothiouronium sulfate under solvent-free conditions

作者：Fujita Mitsue^*; Furusho Yoshio

来源：Tetrahedron, 2018, 74(32): 4339-4342.

DOI：10.1016/j.tet.2018.06.057

• Guanidine
• Solvent-free
• Ultrasound 1H-pyrazole-1-carboxamidine hydrochloride
• S-methylisothiouronium sulfate

We have investigated ultrasound-assisted synthesis of guanidine derivatives using 1H-Pyrazole-1-carboxamidine (PyzCA) and S-substituted isothiouronium sulfate (MeITU). The guanylations of several amines are promoted by ultrasound sonication under solvent-free conditions, and proceed under mild conditions. It is of particular interest that the guanylations do not require bases in most cases.

• 出版日期2018-8-9