A Low Selenium Level Is Associated with Lung and Laryngeal Cancers

作者：Jaworska Katrzyna; Gupta Satish; Durda Katarzyna; Muszynska Magdalena; Sukiennicki Grzegorz; Jaworowska Ewa; Grodzki Tomasz; Sulikowski Mieczyslaw; Woloszczyk Piotr; Wojcik Janusz; Lubinski Jakub; Cybulski Cezary; Debniak Tadeusz; Lener Marcin; Morawski Antoni W; Krzystolik Karol; Narod Steven A; Sun Ping; Lubinski Jan; Jakubowska Anna^*

来源：PLos One, 2013, 8(3): e59051.

DOI：10.1371/journal.pone.0059051

Purpose: It has been suggested that selenium deficiency is a risk factor for several cancer types. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 95 cases of lung cancer, 113 cases of laryngeal cancer and corresponding healthy controls.
Methods: We measured the serum level of selenium and established genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15). Selenium levels in the cases were measured after diagnosis but before treatment. We calculated the odds of being diagnosed with lung or laryngeal cancer, conditional on selenium level and genotype.
Results: Among lung cancer cases, the mean selenium level was 63.2 mu g/l, compared to a mean level of 74.6 mu g/l for their matched controls (p<0.0001). Among laryngeal cancer cases, the mean selenium level was 64.8 mu g/l, compared to a mean level of 77.1 mu g/l for their matched controls (p<0.0001). Compared to a serum selenium value below 60 mu g/l, a selenium level above 80 mu g/l was associated with an odds ratio of 0.10 (95% CI 0.03 to 0.34; p = 0.0002) for lung cancer and 0.23 (95% CI 0.09 to 0.56; p = 0.001) for laryngeal cancer. In analysis of four selenoprotein genes we found a modest evidence of association of genetic variant in GPX1 with the risk of lung and laryngeal cancers.
Conclusion: A selenium level below 60 mu g/l is associated with a high risk of both lung and laryngeal cancer.

• 出版日期2013-3-13