A New Modified CKD-EPI Equation for Chinese Patients with Type 2 Diabetes

作者：Liu, Xun; Gan, Xiaoliang; Chen, Jinxia; Lv, Linsheng; Li, Ming; Lou, Tanqi^*

来源：PLos One, 2014, 9(10): e109743.

DOI：10.1371/journal.pone.0109743

• GLOMERULAR-FILTRATION-RATE
• RENAL-DISEASE
• DIET
• EPIDEMIOLOGY

Objective: To improve the performance of glomerular filtration rate (GFR) estimating equation in Chinese type 2 diabetic patients by modification of the CKD-EPI equation. @@@ Design and patients: A total of 1196 subjects were enrolled. Measured GFR was calibrated to the dual plasma sample Tc-99m-DTPA-GFR. GFRs estimated by the re-expressed 4-variable MDRD equation, the CKD-EPI equation and the Asian modified CKD-EPI equation were compared in 351 diabetic/non-diabetic pairs. And a new modified CKD-EPI equation was reconstructed in a total of 589 type 2 diabetic patients. @@@ Results: In terms of both precision and accuracy, GFR estimating equations all achieved better results in the non-diabetic cohort comparing with those in the type 2 diabetic cohort (30% accuracy, P <= 0.01 for all comparisons). In the validation data set, the new modified equation showed less bias (median difference, 2.3 ml/min/1.73 m(2) for the new modified equation vs. ranged from -3.8 to -7.9 ml/min/1.73 m(2) for the other 3 equations [P < 0.001 for all comparisons]), as was precision (IQR of the difference, 24.5ml/min/1.73 m(2) vs. ranged from 27.3 to 30.7 ml/min/1.73 m(2)), leading to a greater accuracy (30% accuracy, 71.4% vs. 55.2% for the re-expressed 4 variable MDRD equation and 61.0% for the Asian modified CKD-EPI equation [P = 0.001 and P = 0.02]). @@@ Conclusion: A new modified CKD-EPI equation for type 2 diabetic patients was developed and validated. The new modified equation improves the performance of GFR estimation.

• 出版日期2014-10-14
• 单位中山大学