科研之友
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摘要
Potentially biodegradable graft polymer core-shell nanoparticles assembling by addition of metal ions intended to be used for radionuclide and drug delivery purposes are described. With Cu(2+) ions, the self-assembly is slow (within minutes) with low efficiency. With Fe(3+) ions the nanoparticles are formed immediately and are of convenient size for passive tumor accumulation by the enhanced permeation and retention effect. Full in vitro degradation of these particles is achieved with deferoxamine as a model of in vivo transchelation capacity.
- 出版日期2011-11-1
