Adjunctive lamotrigine therapy for patients with bipolar II depression partially responsive to mood stabilizers

作者：Chang Jae Seung; Moon Eunsoo; Cha Boseok; Ha Kyooseob^*

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010, 34(7): 1322-1326.

DOI：10.1016/j.pnpbp.2010.07.020

• Adjunctive therapy
• Bipolar II disorder
• Depression
• Lamotrigine

This naturalistic study explored long-term effectiveness of adjunctive lamotrigine therapy for bipolar II depression. We analyzed prospective data from 109 lamotrigine-treated outpatients with bipolar II depression inadequately responsive to mood stabilizers Lamotrigine was added to prior treatment in a naturalistic fashion. Changes in depression severity were prospectively monitored for up to 52 weeks using a prospective mood chart and the Clinical Global Impressions-Bipolar Version-Severity (CGI-BP-S) Time to lamotrigine discontinuation during 52-week period was calculated using the Kaplan-Meier estimate A significant reduction in the CGI-BP-S depression score was observed between baseline and week 52 with a large effect size. The discontinuation rates were 440% and 50 5% for the total sample and 14.3% and 229% for responders at 24 weeks and 52 weeks, respectively A higher number of prior hospitalizations for depression and a history of attempted suicide were associated with poor response to adjunctive lamotrigine treatment Sustained benefits of an open-label lamotrigine add-on were indicated in patients with bipolar II depression Adjunctive usage of lamotrigine was safe and generally well-tolerated. The potential benefit of adjunctive lamotrigine treatment was suggested in patients with bipolar II disorder suffering from depressive symptoms.

• 出版日期2010-10-1