Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog

作者：Aldawsari Fahad S^*; Aguiar Rafael Pazinatto; Marques Wiirzler Luiz Alexandre; Aguayo Ortiz Rodrigo; Aljuhani Naif; Nakamura Cuman Roberto Kenji; Medina Franco Jose L; Siraki Arno G; Velazquez Martinez Carlos A

来源：Bioorganic & Medicinal Chemistry Letters, 2016, 26(5): 1411-1415.

DOI：10.1016/j.bmcl.2016.01.069

• Resveratrol
• Chemoprevention
• Inflammation
• Myeloperoxidase
• Salicylate

Resveratrol is a natural compound with a plethora of activities as well as limitations. We recently reported a series of resveratrol-salicylate analogs with potential chemopreventive activity. Herein, we report the anti-inflammatory and antioxidant properties of these resveratrol derivatives. Using an in vitro COX inhibition assay, and two in vivo protocols (carrageenan-induced peritonitis and paw edema), we identified a novel compound (C10) as a potent anti-inflammatory agent. The enhanced potency of C10 was associated with the ability of C10 to decrease the activity of myeloperoxidase (MPO) enzyme at 10 mg/kg, whereas resveratrol and it's natural analog (TMS) did not exert the same effect. Additionally, C10 significantly reduced the concentration of intracellular reactive oxygen species. Because of the proven association between cancer, inflammation, and oxidative stress, we believe that C10 is a promising chemopreventive molecule.

• 出版日期2016-3-1