Dopamine D1 receptors induce apoptosis of osteosarcoma cells via changes of MAPK pathway

作者：Gao, Jun^*; Gao, Feng

来源：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2017, 44(11): 1166-1168.

DOI：10.1111/1440-1681.12814

• apoptosis
• dopamine D1 receptors
• MAPK pathway
• osteosarcoma cells

This study explored the effects and mechanisms of dopamine D1 receptors (DR1) activation on the apoptosis of osteosarcoma cells (OS732).The DR1 agonist SKF-38393 decreased the viability of OS732 cells and increased their rate of apoptosis, whereas the DR1 antagonist SCH-23390 abolished the effects of SKF-38393. In OS732 cells, overexpression of DR1 increased the rate of apoptosis, caspase-9 and -3 expression, and the release of cytochrome c (Cyt c), reduced Bcl-2 expression, inhibited extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation, and induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinase (JNK). These results suggest that activation of DR1 induces osteosarcoma cell apoptosis via changes to the MAPK pathway.

• 出版日期2017-11
• 单位哈尔滨医科大学; 哈尔滨市第一医院