A Randomized, Double-Blind, Crossover Comparison of MK-0929 and Placebo in the Treatment of Adults With ADHD

作者：Rivkin Anna^*; Alexander Robert C; Knighton Jennifer; Hutson Pete H; Wang Xiaojing J; Snavely Duane B; Rosah Thomas; Watt Alan P; Reimherr Fred W; Adler Lenard A

来源：Journal of Attention Disorders, 2012, 16(8): 664-674.

DOI：10.1177/1087054711423633

• Attention Deficit Hyperactivity Disorder (ADHD)
• AISRS rating scale
• dopamine D4 receptor (DRD4) antagonist
• genotyping

Objective: Preclinical models, receptor localization, and genetic linkage data support the role of D4 receptors in the etiology of ADHD. This proof-of-concept study was designed to evaluate MK-0929, a selective D4 receptor antagonist as treatment for adult ADHD. Method: A randomized, double-blind, placebo-controlled, crossover study was conducted in adults with primary ADHD. The primary end point was changed from baseline in total score on the Adult ADHD Investigator Symptom Rating Scale following a 4-week treatment regimen. Additional measures included Clinical Global Impression-Severity Scale, Hospital Anxiety and Depression Scale, and Brown Attention Deficit Disorder Scale and D4 genotype analysis. Results: No statistically significant treatment differences were found between MK-0929 and placebo in any of the primary or secondary assessments. Conclusion: Results from this study suggest that blockade of the D4 receptor alone is not efficacious in the treatment of adult ADHD. (J. of Att. Dis. 2012; 16(8) 664-674)

• 出版日期2012-11