A New Antimicrobial Fatty Acid from the Calcareous Sponge Paragrantia cf. waguensis

作者：Tianero Ma Diarey B; Hanif Novriyandi; de Voogd Nicole J; van Soest Rob W A; Tanaka Junichi^*

来源：Chemistry and Biodiversity, 2009, 6(9): 1374-1377.

DOI：10.1002/cbdv.200800199

A new acetylenic fatty acid, 1, has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT-72 rat bladder epithelial cells (IC(50) > 20 mu g/ml), and antimicrobial activity with minimal-inhibitory concentrations (MIC) of 64 and 128 mu g/ml against Staphylococcus aureus and Escherichia coli, respectively.

• 出版日期2009