Abnormally high EEG alpha synchrony during working memory maintenance in twins discordant for schizophrenia

作者：Bachman Peter^*; Kim Junghoon; Yee Cindy M; Therman Sebastian; Manninen Marko; Lonnqvist Jouko; Kaprio Jaakko; Huttunen Matti O; Naatanen Risto; Cannon Tyrone D

来源：Schizophrenia Research, 2008, 103(1-3): 293-297.

DOI：10.1016/j.schres.2008.04.006

• schizophrenia
• electrophysiology
• working memory
• twin
• efficiency
• alpha synchronization
• inhibition
• interference resolution

Background: The present analyses aimed to test the prediction that schizophrenia patients and their non-schizophrenic co-twinswould display reduced efficiency of the neurocognitive mechanisms subserving active maintenance of spatial information in working memory. Methods Upper alpha frequency band EEG event-related desynchronization and synchronization (ERD/ERS) were calculated as percent changes in power relative to an inter-trial baseline across 4 memory loads in a spatial delayed-response task. Results: During the delay, the diagnostic groups showed equivalent ERD/ERS activity over posterior scalp regions at the lowest memory load; however, as memory load increased, patients, and to an intermediate degree, their non-schizophrenic co-twins (monozygotic and dizygotic pairs collapsed together), showed significantly greater increases in ERD/ERS amplitude as compared with controls. Conclusions: These findings dernonstrate abnormally increased ERWERS amplitudes with increasing memory load in patients with schizophrenia and their co-twins, consistent with inefficiency of the neurocognitive mechanisms supporting active maintenance of information across a delay.

• 出版日期2008-8