A quality marker study on salvianolic acids for injection

作者：Li, Wei; Polachi, Navaneethakrishnan; Wang, Xiangyang; Chu, Yang; Wang, Yuan; Tian, Meng; Li, Dekun; Zhou, Dazheng; Zhou, Shuiping; Ju, Aichun; Li, Yubo; Zhang, Yanjun; Chen, Min; Huang, Luqi^*; Liu, Changxiao^*

来源：Phytomedicine, 2018, 44: 138-147.

DOI：10.1016/j.phymed.2018.02.003

• Q-Marker
• Salvianolic acids for injection
• Chinese medicine
• Quality standard
• Pharmacological action
• Pharmacokinetics

Background: The quality of Chinese medicine (CM) has being an active and challenging research area for CM. Prof. Chang-Xiao Liu a al first proposed the concept of quality marker (Q-Marker) for the quality evaluation and control on CM. This article describe the exploratory studies of Q-Marker in salvianolic acids for injection (SAI) based on this new concept. @@@ Purpose: This study was designed to screen Q-Marker of SAI and establish its quality control method based on the concept of CM Q-Marker. @@@ Methods: Based on the concept of CM Q-Marker, the SAI was investigated for the identification of chemical components and their sources. The pharmacological effects on cerebral ischemia and reperfusion induced injury in rats were also investigated. Furthermore, the target cell extracts and pharmacokinetic studies were conducted to screen Q-Markers. Finally, the fingerprints and determination based on Q-Markers were established to assess the quality of SAI more effectively. @@@ Results: Overall, 20 constituents in SAI were identified. It was found that salvianolic acid B (SA-B), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid D (SA-D) and salvianolic acid Y (SA-Y) are major chemical components of SAL Based on chemical components identifications, analysis of their sources, target cell extracts and pharmacokinetic studies, four phenolic acids, namely SA-B, RA, LA and SA-D, were screened and determined as effective Q-Markers of SAI. @@@ Conclusion: This study demonstrated that the described method is a powerful approach for detecting Q-Markers, which can be used as control index for the quality assessment of CM.

• 出版日期2018-5-15
• 单位天津药物研究院有限公司; 中国中医科学院; 天津中医药大学