Novel ferrocenyl nitroxide nanoparticles as electron paramagnetic resonance oximetry probes in vitro and in vivo

作者：Qiu, Xiao; Zhao, Hongli; Yu, Ronghua; Zhang, Jiufeng; Lan, Minbo^*

来源：Nanomedicine, 2011, 6(2): 225-231.

DOI：10.2217/NNM.11.2

• EPR oximetry
• ferrocenyl nitroxide radicals
• in vitro
• in vivo
• nanoparticles
• Pluronic F-127

Aims: In this article we report our recent developments in the field of electron paramagnetic resonance oximetry. Materials & methods: Novel synthesized ferrocenyl nitroxide radicals (FcN)-1-6 were evaluated to determine their electron paramagnetic resonance oxygen responsiveness and reduction resistance. The 3-ferrocenyl-N-(oxyl-2,2,6,6-tetramethylpiperidin-4-yl) butanamide radical (FcN-6), with outstanding electron paramagnetic resonance oxygen sensitivity, was encapsulated in Pluronic F-127 polymeric nanoparticles. Results: The nanoparticles exhibited good oxygen sensitivity, long-term stability of responsiveness, targeting to lung, liver and tumor, and low toxicity. Conclusion: These features make this novel nanoparticle especially valuable for mapping O-2 concentrations in the body and monitoring the oxygen level inside tissues.

• 出版日期2011-2
• 单位中国科学院长春应用化学研究所; 华东理工大学