Antitrypanosomal Triterpenoid with an epsilon-Lactone E-Ring from Salvia urmiensis

作者：Farimani Mahdi Moridi^*; Ebrahimi Samad Nejad; Salehi Peyman; Bahadori Mir Babak; Sonboli Ali; Khayasi Hamid Reza; Zimmermann Stefanie; Kaiser Marcel; Hamburger Matthias

来源：Journal of Natural Products, 2013, 76(9): 1806-1809.

DOI：10.1021/np400337a

A new triterpenoid, urmiensolide (1), was isolated from Salvia urmiensis. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute configuration was established by comparison of experimental and simulated ECD spectra. Urmiensolide is the first pentacyclic triterpenoid bearing a epsilon-lactone E-ring. The compound showed in vitro antitrypanosoal activity with an IC50 value of 5.6 mu M against the Trypanosoma brucei rhodesiense STIB 900 strain and a selectivity index of 33. A possible biosynthetic pathway of 1 from a-amyrin is proposed.

• 出版日期2013-9