科研之友
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摘要
The CuBr2-catalyzed enantioselective allenylation of terminal alkynols with carbon chains of different lengths has been developed. Compared with (S)-,-diphenylprolinol, the reaction using (S)-,-imethylprolinol as the chiral amine afforded optically active 1,3-disubstuted allenols with higher ee-values. Both aliphatic and aromatic aldehydes could be applied. The naturally occurring phlomic acid was synthesized in four steps from commercially available hex-5-yn-1-ol.
- 出版日期2018-7
- 单位浙江大学
