科研之友
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摘要
The plant Gymnema sylvestre has been used widely in traditional medicine as a remedy for several diseases, and its leaf extract is known to contain a group of bioactive triterpene saponins belonging to the gymnemic acid class. Gymnemic acid I (1) is one of the main components among this group of secondary metabolites and is endowed with an interesting bioactivity profile. Since there is-a lack of information about its specific biological targets, the full interactome of 1 was investigated through a :quantitative chemical proteomic approach, based on stable-isotope dimethyl labeling. The ribosome complex was found to be the main partner of compound 1, and a full valiolation of the proteomics results was achieved by orthogonal-approaches. Further biochemical and biological investigations revealed-an inhibitory effect of 1 on the ribosome machinery.
- 出版日期2017-4
