Fabrication of AIE-active fluorescent organic nanoparticles through one-pot supramolecular polymerization and their biological imaging

作者：Xu, Dazhuang; Liu, Meiying; Zou, Hui; Huang, Qiang; Huang, Hongye; Tian, Jianwen; Jiang, Ruming; Wen, Yuanqing^*; Zhang, Xiaoyong^*; Wei, Yen^*

来源：Journal of the Taiwan Institute of Chemical Engineers, 2017, 78: 455-461.

DOI：10.1016/j.jtice.2017.05.024

• Fluorescent organic nanoparticles
• Aggregation-induced emission
• Supramolecular polymerization
• Biological imaging

Supramolecular interactions between individual molecules are universal forces in living organisms and have been extensively investigated and utilized for fabrication of multifunctional materials over the past few decades. In this work, we reported a rather facile strategy to fabricate the fluorescent organic nanoparticles (FONs) with red fluorescence and aggregation-induced emission (AlE) feature through the supramolecular interactions between the beta cyclodextrin (beta-CD) and adamantine terminating AIE dye. The structures of prepared Ph-Ad/beta-CD FONs were characterized by H-1 nuclear magnetic resonance (NMR) and Fourier transform infrared spectroscopy (FTIR) spectroscopy. The size and morphology of the final self-assemblies (named as Ph-Ad/beta-CD FONs) was characterized by transmission electronic microscopy (TEM). Results demonstrated that these AIE-active FONs can self-assemble into nanoparticles with excellent dispersity and strong fluorescence due to their AIE feature. Biological evaluation demonstrated that Ph-Ad/beta-CD FONs has superior biocompatibility and imaging performance. These features endow the Ph-Ad/beta-CD FONs good performance in biomedical fields.

• 出版日期2017-9
• 单位清华大学; 南昌大学