A Flexible Depth Probe Using Liquid Crystal Polymer

作者：Lee Sung Eun; Jun Sang Beom; Lee Hyun Joo; Kim Jinhyung; Lee Seung Woo; Im Changkyun; Shin Hyung Cheul; Chang Jin Woo; Kim Sung June^*

来源：IEEE Transactions on Biomedical Engineering, 2012, 59(7): 2085-2094.

DOI：10.1109/TBME.2012.2196274

• Liquid crystal polymer (LCP)
• neural depth probe
• polymer-based depth probe

We proposed a method of making a flexible depth-type neural probe using liquid crystal polymer. Conventional depth neural probes made of metal or silicon have the limitations of a single recording site per shank or the brittleness of the silicon substrate. To avoid these drawbacks, polymer-based depth neural probes have been developed with biocompatible polymers such as polyimides or parylenes. However, those have suffered from the difficulty of inserting the probes into brain tissues due to their high flexibility, requiring mechanical reinforcements. Herein, we report the first attempt to use a flexible material, liquid crystal polymer (LCP), as a substrate for a depth-type neural probe. The LCP-based probe offers a controllable stiffness vs. flexibility and compatibility with thin-film processes in addition to its inherent characteristics such as high reliability and biocompatibility. In the present study, an LCP neural probe was fabricated to have enough stiffness to penetrate the dura mater of rodent brains without a guide tool or additional reinforcement structures. A simultaneous multichannel neural recording was successfully achieved from the somatosensory motor cortex of the rodents. Immunohistochemistry showed that the electrodes could be inserted into the desired regions in the brain.

• 出版日期2012-7