The Seville Expert Workshop for Progress in Posttransplant Lymphoproliferative Disorders

作者：Glotz Denis^*; Chapman Jeremy R; Dharnidharka Vikas R; Hanto Douglas W; Castro Maria C R; Hirsch Hans H; Leblond Veronique; Mehta Aneesh K; Moulin Bruno; Pagliuca Antonio; Pascual Julio; Rickinson Alan B; Russo Francesco P; Trappe Ralf U; Webster Angela C; Zuckermann Andreas O; Gross Thomas G

来源：Transplantation, 2012, 94(8): 784-793.

DOI：10.1097/TP.0b013e318269e64f

• Epstein-Barr virus infection
• Immunosuppression
• Lymphoproliferative disorder
• Transplantation

Posttransplant lymphoproliferative disorders (PTLDs) are associated with significant morbidity and mortality among solid-organ transplant patients, but approaches to diagnosis and management vary considerably. An international multidisciplinary panel evaluated current understanding of risk factors and classification systems and developed recommendations to aid in PTLD prevention. We considered evidence on PTLD risk factors including Epstein- Barr virus serostatus and immunosuppression and identified knowledge gaps for future research. Recommendations address prophylactic and preemptive strategies to minimize PTLD development, including modulation of immunosuppression and antiviral drug regimens. Finally, new classification criteria were outlined that may help facilitate standardized reporting and improve our understanding of PTLD.

• 出版日期2012-10-27